Anticoagulants ‘thin the blood’ or ‘reduce the ability of blood to form clots’
How to take
Apixaban:TWICE a day, with or without food – can be crushed Dabigatran: TWICE a day, with or without food – DO NOT OPEN OR CHEW CAPSULES, DO NOT PUT IN DOSETTE BOX
Edoxaban: ONCE a day, with or without food – ADVISE NOT TO CRUSH (no data)
Rivaroxaban: ONCE a day WITH FOOD – can be crushed
Importance of taking as prescribed – if a dose/day of medicine is missed, the
medicine will not work on that day putting the patient at risk of a stroke
Advise on adherence aids e.g. reminders.
ONCE-daily DOACs(rivaroxaban & edoxaban):
the dose should be taken immediately and then be continued the following day with the once-daily intake as recommended. The patient should not take double the prescribed dose on the same day to make up for a missed dose.
* resume 24 hour dosing from the new time of administration (if the patient wishes to return to their normal time of administration;
the time at which the dose is taken each day may be gradually adjusted by 1 hour/day) *[Verbal advice from manufacturer]
Dabigatran – forgotten dose may still be taken up to 6 hours prior to the next scheduled dose.
From 6 hours prior to the next scheduled dose on, the missed dose should be omitted
Apixaban- If a dose is missed, the patient should take apixaban immediately and then continue with twice daily intake as before.
ESSENTIAL in an emergency situation, planning surgery, planning pregnancy,
dentist, pharmacist (interactions), practice nurse (immunisations)
Signs of bleeding and bruising (seek emergency help if severe) – epistaxis (if lasts